Twist Bioscience

Company Overview

Founded in 2013, Twist Bioscience develops and commercializes next-generation platforms for DNA synthesis. The company is using microarray-based methods to synthesize DNA. Oligonucleotides are synthesized within holes inside of the nano-wells on Twist’s wafer. Oligonucleotides can be combined to build a gene by depositing one oligonucleotide into each of the nano-well holes.

Enzymes for combining the oligonucleotides are also added to the nano-wells. The advantage of this approach is that small volumes of oligonucleotides are used, and the process can be easily scaled up to produce thousands of genes. Each silicon wafer can contain up to 10,000 nano-wells.

Twist is leveraging its gene synthesis platform to create products in other fields, including NGS enrichment and DNA libraries. The company also markets kits for NGS enrichment, oligo pools, and DNA libraries.

Financial Highlights (FY 2024)

Company's Business Segments

• Synthetic genes : Clonal genes of perfect quality are delivered to the customer in a vector vehicle. Genes that customers can place in their own vector, non-clonal genes or fragments.
• Oligo pools : Oligo pools ranging from a few hundred oligos to over one million Offer oligonucleotides of up to 300 nucleotides in length with an error rate of 1:3000 nucleotides.
• DNA libraries : Single-site libraries, Antibody optimization solution, Custom software for the optimization of antibody hits, Antibody compounds that meet pre-specified criteria for therapeutic Development.
• Antibody discovery : Antigen Production, Diversimab Platform, VHH Discovery, Antibody Discovery, Antibody Sequencing.
• NGS tools : This segment includes DNA synthesis platform.