QUANTAPORE

Company Overview

Quantapore Inc., founded in 2009, is developing nanopore-based sequencing technologies.

Quantapore’s platform uses both solid-state and biological nanopores. DNA bases are labeled and detected as they pass through the nanopore. The bases are detected by optical readout from fluorophores that are attached to the DNA. These fluorophores are activated when the DNA exits the pore.

The optical readout is in contrast to Oxford Nanopore Technologies, which uses an electrical readout platform. The advantage of optical readout includes scalability and speed. Scalability is possible because a single CMOS (complementary metal-oxide semiconductor) sensor chip can record signals from all of the pores. The platform does not require a sensor for every nanopore. Speed is possible because the DNA is not slowed down by a motor protein.

The platform requires sample preparation to label the DNA so that the four bases can be distinguished.

Company's Business Segments

• Nanopore-based Analytical Platform : This segment design Single-Molecule, Solid-State Nanopore-Based Analytical Platforms to address key problems developing massively parallel, direct, single molecule protein analytical tools that will improve human health.